KETAMINE NEWS SECRETS

Metabolism Ketamine is metabolized by way of N-dealkylation towards the active metabolite norketamine mainly by CYP2B6 and CYP3A4 also to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation on the cyclohexone ring to type hydroxynorketamine compounds by using CYP-dependent pathways, which are conjugated with glucuronic acid an